396
55
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9919 |
Alemtuzumab
|
Others | Others |
Alemtuzumab 是人源化抗 CD52单克隆抗体, CD52是一种表达于大多数淋巴细胞以及少数的髓细胞类型的糖蛋白。Alemtuzumab 与能够特异性作用于 CD52 抗原,诱导淋巴细胞深度耗竭,恢复具有调节表型的 T 细胞和 B 细胞。。 | |||
T13173 |
TMPA
|
Others; AMPK | Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling |
TMPA 是一种核受体 Nur77 和 LKB1 相互作用的拮抗剂。 | |||
T9720 |
T3Inh-1
|
Others | Others |
T3Inh-1 是一种有效的选择性 ppGalNAc-T3 抑制剂,IC50 为 7 µM。 T3Inh-1 可预防乳腺癌细胞。 T3Inh-1 降低组织细胞和小鼠中的 FGF23 激素水平,而不会引起任何毒副作用。 | |||
T16111 |
ML604086
|
CCR | Immunology/Inflammation; Microbiology/Virology |
ML604086 是选择性CCR8抑制剂,抑制循环T 细胞上 CCL1 与 CCR8 结合,还抑制 CCL1 介导的趋化性并提高细胞内 Ca2 浓度。 | |||
T10425 |
AZ084
|
CCR | Immunology/Inflammation; Microbiology/Virology |
AZ084 是可口服的选择性 CCR8变构拮抗剂,其Ki 值为 0.9 nM,可研究哮喘。 | |||
T16133 |
MRK-560
|
Gamma-secretase | Neuroscience; Proteases/Proteasome; Stem Cells |
MRK-560 是高效的、口服有效的 γ- 分泌酶抑制剂抑制剂,具有大脑屏障渗透性。 | |||
T6255 |
Bromosporine
|
Epigenetic Reader Domain; CDK | Cell Cycle/Checkpoint; Chromatin/Epigenetic |
Bromosporine 是广谱 BRD2/4/9 和 CECR2 溴结构域抑制剂,IC50为0.41、0.29、0.122和0.017 μM。 | |||
T2648 |
Pimecrolimus
SDZ-ASM 981,ASM 981,吡美莫司 |
Others | Others |
Pimecrolimus (SDZ-ASM 981) 是一种免疫亲和素配体,能与胞质受体特异性的结合。 | |||
T6540 |
Ibuprofen Lysine
布洛芬赖氨酸盐,Neoprofen |
COX | Immunology/Inflammation; Neuroscience |
Ibuprofen Lysine (Neoprofen) 是一种非甾体抗炎药。 | |||
T1394 |
Ibuprofen
Brufen,(±)-Ibuprofe,布洛芬,Motrin,Advil |
COX | Immunology/Inflammation; Neuroscience |
Ibuprofen (Advil) 是一种丙酸衍生物和非甾体抗炎药 (NSAID),具有抗炎、镇痛和解热作用。它是COX-1和COX-2的抑制剂,IC50值分别为 13 和 370 μM,导致前列腺素和血栓素前体的形成减少。 | |||
T1389 |
Dyclonine hydrochloride
盐酸达克罗宁,Dyclocaine hydrochloride,Dyclonine HCl |
Sodium Channel; Antibacterial; Antifungal | Membrane transporter/Ion channel; Microbiology/Virology |
Dyclonine hydrochloride (Dyclonine HCl) 是润喉片的有效成分,具有显著的杀菌和杀真菌作用。 | |||
T4976 |
Umbralisib
TGR-1202,RP5264,TGR 1202,TGR1202 |
PI3K | PI3K/Akt/mTOR signaling |
Umbralisib (TGR 1202) 是一种PI3Kδ抑制剂,IC50=22.2 nM,EC50=24.3 nM。它同时可抑制CK1ε,EC50=6.0 μM。 | |||
T5863 |
Indinavir sulfate
L735524 sulfate,MK-639 sulfate,硫酸茚地那韦 |
SARS-CoV; HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Indinavir sulfate (L735524 sulfate) 是一种 HIV 蛋白酶抑制剂。它抑制 HIV-1 蛋白酶,IC50 值为 0.41 nM,Ki 值为 0.24 nM。它也是SARS-CoV 3CLpro 抑制剂,IC50为 1.71 μM。 | |||
T76674 |
Cibisatamab
|
Others | Others |
Cibisatamab 是一种 T 细胞双特异性抗体,可被当作 T 细胞接合器。Cibisatamab 靶向癌细胞上的癌胚抗原 (CEA) 和 T 细胞上的 CD3,当癌细胞表面的 CEA从中等水平到高水平会触发 T 细胞杀伤。Cibisatamab 可用于研究结直肠癌类的实体癌。 | |||
T35885 |
KRM-III
|
Others | Others |
KRM-III 是一种具有口服活性的 T 细胞抗原受体 (TCR) 抑制剂,具有抗炎活性,可有效抑制 TCR 和肉豆蔻酸乙酸酯/佛波霉素/离子霉素诱导的 NFAT 核因子活化和 T 细胞增殖,IC50 约为 5 μM。 | |||
T37587 |
ML 209
|
ROR | Metabolism |
ML-209 是一种视黄酸相关的孤儿受体 RORγ 拮抗剂 (IC50= 1.1 μM)。ML-209 抑制 HEK293t 细胞中 RORγt 转录活性(IC50= 300 nM)。ML-209 不抑制细胞中 RORα。ML-209 对鼠 Th17 细胞分化具有选择性抑制,而不影响幼稚 CD4+ T 细胞分化为 Th1 和调节性 T 细胞。 | |||
T76692 |
Mosunetuzumab
BTCT-4465A |
Others | Others |
Mosunetuzumab (BTCT-4465A) 是一种基于免疫球蛋白 G1 且靶向 CD20 (B 细胞) 和 CD3 (T 细胞) 的人源化抗体。Mosunetuzumab 重定向 T 细胞以接合和消除恶性 B 细胞,可用于研究复发或难治性 (R/R) B 细胞非霍奇金淋巴瘤 (B-NHL)和难治性滤泡性淋巴瘤。 | |||
TP1541L |
BDC2.5 mimotope 1040-31 acetate
BDC2.5 mimotope 1040-31 acetate(329696-49-3 free base) |
Others | Others |
BDC2.5 mimotope 1040-31 acetate(329696-49-3 free base) 一种用于致糖尿病 T 细胞克隆 BDC2.5 的有效激动肽 (mimotope)。它可以刺激 BDC2.5 细胞,使细胞对这种模拟表位表现出良好的反应。 1040-31 肽对 BDC2.5 TCR Tg+(转基因)T 细胞具有特异性。该肽也称为 p31。 | |||
T35362 |
NSC622608
|
Others | Others |
NSC622608 是 V 域 Ig 抑制 T 细胞活化 (VISTA) 的小分子配体,VISTA 是影响 T 细胞攻击肿瘤能力的免疫检查点。 | |||
T9104 |
TJ191
|
Apoptosis | Apoptosis |
TJ191 是一种选择性抗癌试剂,靶向低 TβRIII 表达的恶性T 细胞白血病/淋巴瘤细胞,可研究癌症。 | |||
T77170 |
Siplizumab
MEDI-507 |
Others | Others |
Siplizumab (MEDI-507) 是一种人源化靶向 CD2 的 IgG1 单克隆抗体。Siplizumab 在体外选择性地消耗效应记忆 T 细胞并促进同种异体反应性调节性 T 细胞的相对扩增。Siplizumab 可用于治疗斑块状银屑病。 | |||
T11782 |
KRN2 bromide
|
Others | Others |
KRN2 bromide 是有效的、选择性的 T 细胞激活核因子 (NFAT5) 的抑制剂 (IC50= 100 nM)。KRN2 bromide 可用于研究 NFAT5-介导的慢性关节炎。 | |||
T76924 |
Efalizumab
Hu1124,HU 1124 |
Integrin | Cytoskeletal Signaling |
Efalizumab 是一种新型针对 T 细胞的有效调节剂,是人源化 LFA-1 α 亚基(CD11a)单克隆抗体。Efalizumab 对 T 细胞激活、皮肤T细胞运输和T细胞粘附到角质形成细胞有抑制作用,可用于研究斑块银屑病和银屑病关节炎。 | |||
T72482 |
Dazostinag disodium
|
STING | Immunology/Inflammation |
Dazostinag disodium (TAK-676) 是一种新型干扰素基因刺激剂 (STING) 激动剂,也是一种免疫系统调节剂,具有抗肿瘤活性,可激活树突状细胞、自然杀伤细胞和 T 细胞。 | |||
T77761 |
BMS-502
|
Others | Others |
BMS-502 是一种二酰基甘油激酶 (DGK) α 和 ζ 的强效双重抑制剂, 诱导人和小鼠T细胞的免疫反应,阻断 T 细胞中细胞内检查点信号传导。BMS-502 以剂量依赖的方式刺激免疫反应,可用于研究与免疫相关的疾病。 | |||
T77426 |
Pascolizumab
SB-240683 |
IL Receptor | Immunology/Inflammation |
Pascolizumab (SB-240683) 是一种人源化抗 IL-4 单克隆抗体。Pascolizumab 具有哮喘作用,可用于研究过敏性鼻炎。 | |||
T67892 |
BTB09089
GPR65 agonist (BTB09089) |
GPR; DNA | DNA Damage/DNA Repair; Endocrinology/Hormones; GPCR/G Protein |
BTB09089 (GPR65 agonist ) 是一种 T 细胞死亡相关基因 8 (TDAG8/GPR65) 特异性激动剂。BTB09089 诱导TDAG8 的表达,对 T 细胞和巨噬细胞细胞因子的产生进行调节。 | |||
T3548 |
Epacadostat
INCB 024360,艾卡哚司他,IDO Inhibitor 1 |
IDO; Indoleamine 2,3-Dioxygenase (IDO) | Metabolism |
Epacadostat (INCB 024360) 是选择性的IDO1抑制剂,IC50=71.8 nM。 | |||
T29857 |
Alethine
β-Alethine |
TNF | Apoptosis |
Alethine (β-Alethine) 是一种小分子化合物,具有抗肿瘤活性,可用于治疗肿瘤和感染。 Alethine 诱导的TNFα上调增加T 细胞的细胞毒性。 | |||
T25705 |
Imupedone
LF1695,LF-1695,LF 1695 |
Others | Others |
Imupedone (LF 1695) 是一种合成免疫调节剂,可调节 T 淋巴细胞和巨噬细胞,诱导骨髓前体细胞的 T 细胞分化,增加淋巴细胞对有丝分裂原、抗原和同种异体细胞的增殖反应。 | |||
T76782 |
Mogamulizumab
KW-0761 |
CXCR | Autophagy; GPCR/G Protein; Immunology/Inflammation |
Mogamulizumab (KW-0761) 是一种针对 T 细胞 CC 趋化因子受体 4 的 单克隆抗体。Mogamulizumab 具有抗癌活性,通过抗体依赖性细胞毒性 (ADCC) 消除肿瘤细胞,可用于研究癌症、成人T细胞白血病/淋巴瘤 (ATLL)、皮肤T细胞淋巴瘤(CTCL)。 | |||
T4665 |
Temsavir
BMS626529 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Temsavir (BMS626529) 是一种新型附着抑制剂,靶向 HIV-1 gp120 并阻止其与 CD4+ T 细胞结合。 | |||
T30077 |
Anisperimus
LF 150195,LF-150195,LF 15-0195,LF-15-0195,LF15-0195 |
Caspase | Apoptosis; Proteases/Proteasome |
Anisperimus (LF 15-0195) 是一种免疫抑制剂,通过促进 DISC 水平的 caspase-8 和 caspase-10 激活来增强激活诱导的 T 细胞死亡,通过促进表达 Foxp3 的调节性 CD4 T 细胞的发育来预防中枢神经系统自身免疫。 | |||
TP1549L |
NY-BR-1 p904 A2 acetate(347142-73-8 free base)
|
Others | Others |
NY-BR-1 p904 A2 acetate(347142-73-8 free base) 对这种 NY-BR-1 表位 (p904) 特异的 T 细胞克隆可以识别表达 NY-BR-1 的乳腺肿瘤细胞。 | |||
T28903 |
T-3364366
T 3364366,T3364366 |
Others | Others |
T-3364366 是一种噻吩并嘧啶酮 delta-5 去饱和酶 (Δ5D) 抑制剂,在 HepG2 和 RLN-10 细胞中的 IC50 分别为 1.9 nM 和 2.1 nM。 | |||
TP1978L |
NFAT inhibitor, Cell Permeable aceate
|
Others | Others |
NFAT inhibitor, Cell Permeable aceate 是一种细胞可渗透的活化 T 细胞核因子 (NFAT) 抑制剂。 可用于足细胞和糖尿病肾病的研究。 | |||
T8546 |
BD750
|
JAK; STAT | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
BD750 是免疫抑制剂和JAK3/STAT5的抑制剂,可抑制 IL-2 诱导的、JAK3/STAT5 依赖的 T 细胞增殖,对小鼠和人 T 细胞增殖的IC50值分别为 1.5 和 1.1 μM。 | |||
T11447 |
GNF4877
|
GSK-3; DYRK | Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors |
GNF4877 是一种 DYRK1A (IC50:6 nM) 和 GSK3β (IC50:16 nM) 抑制剂。 它导致激活 T 细胞核因子核输出的阻断和 β 细胞增殖细胞增加。 | |||
T35569 |
CTA 056
|
Apoptosis | Apoptosis |
CTA 056 是白细胞介素-2 诱导的 T 细胞激酶(ITK)抑制剂,抑制小鼠 MOLT-4 异种移植肿瘤的生长,诱导 Jurkat 细胞凋亡,可用于研究自身免疫性疾病和T细胞恶性肿瘤。 | |||
T71703L |
Isomer-Turosteride
Isomer-Turosteride(Isomer-137099-09-3) |
Reductase | Endocrinology/Hormones; Metabolism |
Isomer-Turosteride (Isomer-Turosteride(Isomer-137099-09-3)) 是一种新型 5α- 还原酶抑制剂。Isomer-Turosteride 在成年大鼠中的抗前列腺作用与抑制T向 DHT 的转化有关。Isomer-Turosteride引起前列腺 DHT 的降低,与 T 含量的继发性增加无关。Isomer-Turosteride 具有抗癌活性,可抑制肿瘤细胞的生长。 | |||
TP1600L |
Iα52 acetate(137756-45-7 free base)
|
Others | Others |
Iα52 acetate(137756-45-7 free base) 是一种天然加工的肽,包含鼠 I-Eα 链的 52-68 位残基,可能有助于选择未成熟的 T 细胞。 | |||
T76882 |
Talquetamab
JNJ-64407564,JNJ-7564 |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Talquetamab (JNJ-64407564)是一种用于多发性骨髓瘤的 T 细胞重定向 GPRC5D 双特异性抗体,具有抗肿瘤活性,通过T 细胞的募集和活化诱导 T 细胞介导的杀死表达 GPRC5 的 MM 细胞。Talquetamab 可用于治疗多发性骨髓瘤 (MM)。 | |||
T36944 |
Ara-G
|
Nucleoside Antimetabolite/Analog | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Ara-G 是一种脱氧鸟苷 (GdR) 类似物和核苷类似物,可被 T 淋巴谱系细胞迅速转化为其相应的阿拉伯糖基鸟嘌呤核苷酸三磷酸 (araGTP),从而抑制 DNA 合成和对 T 淋巴母细胞的选择性体外毒性细胞系以及来自 T 细胞急性淋巴细胞白血病 (ALL) 患者的新鲜分离的白血病细胞。 | |||
TQ0007 |
Cintirorgon
LYC-55716 |
ROR | Metabolism |
Cintirorgon (LYC-55716) 是一种首创的、口服有活力的的RORγ选择性激动剂。它通过调节 RORγ 表达的 T 淋巴免疫细胞的基因表达,提高效应子功能,降低免疫抑制,抑制肿瘤生长,提高生存率。 | |||
T77471 |
Tinurilimab
BAY 1834942 |
||
Tinurilimab (Bay 1834942) 是一种单克隆抗体,靶向并抑制 CEACAM6,CEACAM6 属于免疫检查点调节剂。 Tinurilimab 可用于效应 T 细胞对抗肿瘤的研究。 | |||
T24398 |
Lenaldekar
LDK |
Akt; IGF-1R; S6 Kinase | Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
Lenaldekar (LDK) 抑制 T 细胞扩增和自身免疫性脑脊髓炎。 Lenaldekar 导致 PI3 激酶/AKT/mTOR 通路成员的去磷酸化并延迟有丝分裂晚期的敏感细胞。 | |||
T77369 |
Telazorlimab
ISB-830,GBR-830 |
Immunology/Inflammation related | Immunology/Inflammation |
Telazorlimab (GBR-830) 是一种靶向活化 T 细胞上 OX40 共刺激受体的人源化单克隆抗体。Telazorlimab 可用于治疗红斑狼疮和特应性皮炎。 | |||
T10165L |
5-A-RU hydrochloride
5-Amino-6-(D-ribitylamino)uracil hydrochloride |
Others | Others |
5-A-RU hydrochloride (5-Amino-6-(D-ribitylamino)uracil hydrochloride) 是细菌核黄素的中间体,可激活粘膜相关不变 T 细胞(MAIT)。5-A-RU 可用于研究乳腺癌和前列腺癌。 | |||
T24793 |
SIRT6-IN-5
SIRT6 inhibitor5,SIRT6 IN 5,SIRT6 inhibitor-5,SIRT6 inhibitor 5 |
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
SIRT6-IN-5(SIRT6 inhibitor 5) 是一种具有有效性和选择性的 SIRT6 抑制剂 ,IC50 值为 34 μM。SIRT6-IN-5 具有免疫抑制和化疗增敏作用,可增加 H3K9 的乙酰化并增加培养细胞中的葡萄糖摄取,减少 T 细胞增殖。 | |||
T77760 |
BMS-684
|
Others | Others |
BMS-684 是一种选择性和高效性的 DGKα 抑制剂(IC50:15 nM),具有潜在的抗肿瘤活性,BMS-684 抑制 DGKα 激酶、DGKβ 和 DGKγ。BMS-684 可激活T细胞,可预防和治疗免疫相关疾病。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1768 |
Iriflophenone
|
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
Iriflophenone 是从 Aquilaria sinensis 中分离得到,能诱导 MCF-7 和 T-47D 人乳腺癌细胞增殖。 | |||
T6S1885 |
Benzoylmesaconine
Mesaconine 14-benzoate,苯甲酰新乌头原碱 |
Others | Others |
Benzoylmesaconine (Mesaconine 14-benzoate) 是乌头汤最丰富的组分。其中乌头汤可用于研究类风湿性关节炎。 | |||
TN1110 |
Shanziside
山栀苷,Shanzhiside |
IL Receptor | Immunology/Inflammation |
Shanziside (Shanzhiside) 是一种分离自福洛美属植物中的环烯醚萜苷类化合物。 | |||
T14193 |
α-Galactosylceramide
KRN7000,α-GalCer |
Others | Others |
α-Galactosylceramide (KRN7000) 是一种具有抗肿瘤和免疫刺激作用的合成糖脂。它是一种高效的 NKT 细胞激动剂,可与 CD1d 有效结合。它与 CD1d 的复合物可与 NKT 细胞的 T 细胞抗原受体结合。 | |||
T14854 |
Caerulomycin A
浅蓝霉素,Cerulomycin,Caerulomycin |
Antifungal | Microbiology/Virology |
Caerulomycin A (Caerulomycin) 是抗真菌和抗细菌化合物,能够诱导 T 细胞的产生。它能够抑制 IFN-γ 诱导的 STAT1 通路,从而增强 TGF-β-Smad3 信号通路。它可用于自身免疫病的研究。 | |||
TL0013 |
Heraclenin
独活内酯 |
Anti-infection; Immunology/Inflammation related | Immunology/Inflammation; Microbiology/Virology |
Heraclenin 是一种天然呋喃香豆素。它浓度依赖性的靶向激活的 T 细胞核因子 (NFAT) ,抑制人原代 T 细胞中 T 细胞受体介导的增殖。 | |||
T5681 |
ETHYL CAFFEATE
咖啡酸乙酯,ETHYL 3,4-DIHYDROXYCINNAMATE |
NF-κB; COX; PGE Synthase; NO Synthase | Immunology/Inflammation; Neuroscience; NF-κB |
Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) 是从鬼针草分离的一种酚类天然产物,在体外或在小鼠皮肤中抑制NF-κB 活化及其下游炎症介质的诱导型一氧化氮合酶、环氧合酶 2 和前列腺素 E2。 | |||
TN6393 |
fulvotomentoside A
|
Others | Others |
fulvotomentoside A 可降低肠道中 IL-6 和 IL-17A 的过表达,并显着增加调节性 T 细胞特异性转录因子 Foxp3 的表达。这可能是Ful 改善肠道炎症的机制之一。 | |||
TQ0131 |
Rocaglamide
Rocaglamide A,楝酰胺,Roc-A |
HSP; NF-κB; PERK | Apoptosis; Cytoskeletal Signaling; Metabolism; NF-κB |
Rocaglamide (Roc-A) 是从米仔兰中分离出来的一种天然产物,具有抗癌特性,可用于咳嗽,受伤,哮喘和炎症性皮肤病。它是一种有效的选择性热休克因子 1 活化抑制剂,IC50约为 50 nM。它是 T 细胞中 NF-κB 活化的有效抑制剂,还抑制翻译起始因子eIF4A 的功能。 | |||
TN3209 |
3′,4′,7-Trihydroxyflavone
|
ATPase; Others; p38 MAPK; NF-κB | MAPK; Membrane transporter/Ion channel; NF-κB; Others |
3',4',7-Trihydroxyflavone 是分离自蚕豆荚的黄酮苷元化合物。 | |||
TN2244 |
Sulfuretin
硫黄菊素 |
NF-κB; Autophagy | Autophagy; NF-κB |
Sulfuretin 是竞争性单酚酶和二酚酶活性抑制剂,IC50=13.64 μM。它通过抑制NF-κB 通路来抑制炎症反应。 它可用于过敏性气道炎症的研究。它减少氧化应激、血小板聚集和诱变。 | |||
T1257 |
Bestatin
Ubenimex,乌苯美司 |
Others; Aminopeptidase; Antibacterial; Antibiotic; LTR | Immunology/Inflammation; Metabolism; Microbiology/Virology; Others |
Bestatin (Ubenimex) 是 CD13 (Aminopeptidase N)/APN 和 leukotriene A4 hydrolase 抑制剂,可用于癌症研究。 | |||
T0798 |
Triamcinolone
Fluoxyprednisolone,曲安西龙,Aristocort,Rodinolone |
Glucocorticoid Receptor; COX | Endocrinology/Hormones; Immunology/Inflammation; Neuroscience |
Triamcinolone (Aristocort) 是一种皮质类固醇激素受体激动剂,也是一种合成的长效糖皮质激素,具有抗炎活性。 | |||
T2S2173 |
(E)-Naringenin chalcone
Isosalipurpol,柚皮苷查尔酮,Chalconaringenin,trans-2'4'6'4-tetrahydroxychalcone,柚皮素查耳酮 |
Others | Others |
Naringenin chalcone (Isosalipurpol) 是一种黄酮醇生物合成的中间体,在查耳酮异构酶的作用下,自发代谢成柚皮素。它具有抗炎和抗过敏活性。 | |||
T3824 |
Jaceosidin
|
Apoptosis; BCL; COX; UGT | Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience |
Jaceosidin 是从毛莲蒿中得到的一种黄酮类天然产物,可激活Bax,下调 Mcl-1 和 c-FLIP 的表达,诱导癌细胞凋亡。它能够降低炎性因子水平,激活 NF-κB,抑制COX-2的表达,具有抗癌和抗炎作用。 | |||
TJS1779 |
Protosappanin A
原苏木素A,PTA |
NADPH-oxidase; IL Receptor; IκB/IKK; TNF; NF-κB; TLR; ROS; COX; HIV Protease; JAK; NO Synthase; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome; Stem Cells |
Protosappanin A (PTA) 是从苏木中分离得到的免疫抑制成分和主要联苯化合物,通过下调 JAK2和 STAT3的磷酸化,抑制 JAK2/STAT3依赖的炎症通路。 | |||
T2S0843 |
Negletein
黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether |
IL Receptor; TNF; NOS; Interleukin | Apoptosis; Immunology/Inflammation |
Negletein (7-O-Methylbaicalein) 一种神经保护剂,可增强神经生长因子的作用并诱导 PC12 细胞中的神经突生长。它通过抑制TNF-α和IL-1β表现出抗炎活性,其 IC50值分别为 16.4 和 10.8 μM。它还具有抗菌、抗缺氧和抗阿尔茨海默病活性。 | |||
T37280 |
PE(18:1(9Z)/0:0)
|
Endogenous Metabolite | Metabolism |
PE(18:1(9Z)/0:0) 是一种天然存在的溶血磷脂,是缩醛磷脂溶血磷脂酰乙醇胺的类似物。 PE(18:1(9Z)/0:0) 以浓度依赖性方式诱导 PC12 大鼠神经元细胞中细胞内钙的瞬时增加。 PE(18:1(9Z)/0:0) 增加 IL-4 和 IL-2 的产生,但不增加 IFN-γ 的产生。 在小鼠血清中,PE(18:1(9Z)/0:0)(1 μg/动物)诱导 T 辅助细胞 2 反应。 在寒冷暴露三天后,小鼠肩胛间棕色脂肪组织中的 PE(18:1(9Z)/0:0) 水平增加。 | |||
T8264 |
3-Methyl-2-oxovaleric acid
|
Endogenous Metabolite | Metabolism |
3-Methyl-2-oxovaleric acid 是神经毒素,代谢毒素和酸性原,它是支链氨基酸不完整分解产生的异常代谢物。 | |||
T2S2215 |
Crebanine
|
Apoptosis; Others; Akt | Apoptosis; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling |
Crebanine 是来自于韦诺萨千金藤的一种生物碱,通过抑制 MAPKs 和 Akt 信号通路表现出抗炎活性,还具有抗心律失常的作用。它可诱导人类癌细胞的 G1阻滞和凋亡。 | |||
T3S2016 | Epoxylathyrol | Others | Others |
Epoxylathyrol derivatives have modulation of ABCB1-mediated multidrug resistance in human colon adenocarcinoma and mouse T-Lymphoma cells. | |||
T68351 | Homodestcardin | ||
Homodestcardin is a cyclic depsipeptide fungal metabolite that has been found in T. roseum and has immunosuppressant activity. It inhibits concanavalin A-induced proliferation of isolated mouse T cells. | |||
TN1670 |
Ganodermanondiol
灵芝酮二醇 |
HIV Protease; Nrf2; AMPK | Chromatin/Epigenetic; Immunology/Inflammation; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated antioxidant enzymes and AMPK. | |||
T11365 |
Ganodermanontriol
|
Others | Others |
Ganodermanontriol, a sterol derived from Ganoderma lucidum, showcases hepatoprotective activity and possesses anti-inflammatory properties in tert-butyl hydroperoxide (t-BHP)-damaged hepatic cells through the upregulation of HO-1 expression. | |||
T38243 | Hygrolidin | ||
Hygrolidin is a macrocyclic lactone originally isolated from S. hygroscopicus. It inhibits proliferation of a variety of cancer cell lines, including DLD-1 colon cancer, LNCaP prostate cancer, and K562 leukemia cells (IC50s = 2.9, 5.2, and 33 ng/ml, respectively). Hygrolidin induces the expression and levels of p21 in DLD-1 cells, but not WI-38 fibroblasts, and leads to cell accumulation in the G1 and S phases without inducing apoptosis. It has antiparasitic activity against T. cruzi, L. donovan... | |||
T38838 |
QS-21
Stimulon,QS-21 |
||
QS-21, an immunostimulatory saponin, is a powerful vaccine adjuvant that stimulates both Th2 humoral and Th1 cell-mediated immune responses by interacting with antigen presenting cells (APCs) and T cells. Additionally, QS-21 activates the NLRP3 inflammasome, leading to the release of cytokines IL-1β and IL-18, which are dependent on caspase-1. | |||
T14003 |
15-Acetoxyscirpenol
|
Caspase | Apoptosis; Proteases/Proteasome |
15-Acetoxyscirpenol, a member of the acetoxyscirpenol moiety mycotoxins (ASMs), potently induces apoptosis and inhibits the growth of Jurkat T cells in a dose-dependent manner. This effect is mediated through the activation of caspases independent of caspase-3[1]. | |||
TN4778 |
Physalin H
|
gp120/CD4; Antifection; Autophagy | Autophagy; Immunology/Inflammation; Microbiology/Virology |
Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR induction activity) value of 3.74±0.02. Physalin H shows immunosuppressive effects on T cells both | |||
TN4457 | Lucidal | Others | Others |
Lucialdehyde C (Lucidal) exhibits potent cytotoxicity against LLC, T-47D, Sarcoma 180, and Meth-A tumor cells with ED(50) values of 10.7, 4.7, 7.1, and 3.8 microg/ml, respectively. | |||
T14063 |
7α,25-Dihydroxycholesterol
7α,25-OHC |
EBI2/GPR183; Endogenous Metabolite | GPCR/G Protein; Metabolism |
7α,25-Dihydroxycholesterol 是一种孤儿 GPCR 受体EBI2 (GPR183)的内源性配体和有效选择性激动剂。它对激活 EBI2 有很强的作用 (EC50=140 pM;Kd=450 pM)。它能够作为一种趋化因子,指导 B 细胞、T 细胞和树突状细胞的迁移。 | |||
T35910 |
Petromurin C
|
||
Petromurin C is a bis-indolyl benzenoid fungal metabolite originally isolated from the ascostromata of P. muricatus. It is cytotoxic to NS-1 mouse myeloma cells (IC50 = 33 μg/ml) and has activity against T. foetus in vitro (IC50 = 100 μg/ml). | |||
TN3723 | Cryptomeridiol | PAFR; Antifection | GPCR/G Protein; Microbiology/Virology |
Cryptomeridiol is a potential skin-whitening agent, exhibits melanogenesis inhibitory activity on α-MSH-stimulated B16 melanoma cells. Cryptomeridiol has low activity against A. niger, T. mentagrophytes, and C. albicans. (-)-Cryptomeridiol also exhibits a significant and concentration-dependent inhibitory effect on PAF receptor binding, with inhibitory concentration (IC)(50) values of 17.5 uM. | |||
TN3721 |
Cryptofolione
|
Antifection | Microbiology/Virology |
Z-Cryptofolione and Cryptomoscatone D2 as highly efficacious inhibitors of the G(2) checkpoint, G(2) checkpoint inhibitors can force cells arrested in G(2) phase by DNA damage to enter mitosis. Cryptofolione shows moderate cytotoxicity in both macrophages and T. cruzi amastigotes, it also displays a mild inhibitory effect on the promastigote form of Leishmania spp. | |||
T75661 | Thymopentin acetate | ||
Thymopentin acetate为胸腺皮质及髓质上皮细胞主要分泌的生物活性肽,是一有效免疫调节剂,具有极短的血浆半衰期(30秒),能促进自人类胚胎干细胞生成T细胞群。 | |||
TN1663 |
Ganoderic acid DM
灵芝酸DM,灵芝酸 DM |
PARP; Androgen Receptor; CDK | Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Endocrinology/Hormones |
Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1), this suppression leads to the inhibition of dendritic cell-specific transmembrane pr | |||
TN5498 |
6,7,4'-Trihydroxyflavanone
|
Others | Others |
6,7,4'-Trihydroxyflavanone 具有多种药理活性,包括抗风湿、抗缺血、抗炎、抗破骨细胞和对 METH 诱导的 T 细胞失活的保护作用。 6,7,4'-三羟基黄烷酮可用于研究治疗患有神经退行性疾病的 METH 成瘾者。 | |||
T21441 |
Prostratin
12-Deoxyphorbol-13-acetate |
||
Prostratin, a protein kinase C activator, has been shown to exhibit promising therapeutic potential against other diseases such as cancer and Alzheimer's disease. Prostratin has the potential to be useful in the treatment of HIV as it could flush viral re | |||
T36961 |
Malformin C
|
||
Malformin C is a natural fungus-derived bicyclic pentapeptide that has antibacterial properties, particularly against species of Bacillus. Malformin C potently blocks the ability of bleomycin to induce G2 arrest in human T-cell leukemia-derived Jurkat cells (IC50 = 0.9 nM). It less potently abrogates colchicine-induced M phase arrest in Jurkat cells (IC50 = 24 nM). Malformin C inhibits cell growth dose-dependently in Colon 38 and HCT 115 cancer cells (IC50s = 0.27 and 0.18 μM, respectively) but ... | |||
TMA1008 |
Ganoderic acid S
|
Others | Others |
A novel combination of triterpenoids includes at least ganoderic acid S (GAS), ganoderic acid T (GAT), ganoderic acid Me (GAMe), ganoderic acid R (GAR), and ganodermic acid S (GMAS), the composition is suitable for the treatment or prophylaxis of colon ca | |||
TN5880 |
Mesuol
|
||
Mesuol has antioxidant activity, it shows very high scavenging activity against DPPH radical; it also has immunomodulatory activity, can potentiate percentage neutrophil adhesion in neutrophil adhesion test in rats and phagocytosis in carbon clearance assay. Mesuol can suppress HIV-1 replication in Jurkat T cells, it inhibits TNFα-induced HIV-1-LTR transcriptional activity by targeting the nuclear factor-κB (NF-κB) pathway. | |||
T36845 |
Isogarcinol
|
||
Isogarcinol is a natural polyisoprenylated benzophenone first isolated from plant species in the genus Garcinia. It has immunosuppressant actions, inhibiting the protein phosphatase calcineurin (IC50 = 36 μM) and suppressing the proliferation of T cells. Oral administration of isogarcinol in mice decreases delayed type hypersensitivity, prolongs graft survival in allogeneic skin transplants, suppresses inflammation in collagen-induced arthritis, and reduces clinical symptoms in experimental auto... | |||
T75632 | Ganoderic acid T1 | ||
Ganoderic acid T1是Ganoderic acid T的去乙酰化衍生物,具有促进癌细胞凋亡(apoptosis)的功能。它通过降低线粒体膜电位以及激活caspase-9和caspase-3来引发细胞凋亡,并增加细胞内ROS的产生,从而表现出促氧化活性和细胞性毒作用,同时减弱抗氧化防御系统。 | |||
TN2190 |
Scoulerine
|
Apoptosis; Beta-Secretase; BACE; Parasite | Apoptosis; Microbiology/Virology; Neuroscience |
Scoulerine 是抗有丝分裂化合物。它抑制细胞增殖,阻止细胞周期,并诱导癌细胞凋亡。它也是BACE1(淀粉样前体蛋白裂解酶 1) 的抑制剂。 | |||
T73402 |
Flavipin
|
||
Flavipin 是一种芳香烃受体(Ahr)激动剂,可诱导小鼠 CD4+T 细胞和 CD11b+巨噬细胞表达 Ahr 下游基因。Flavipin 抑制 Arid5a 在 Il23a3'UTR 上的稳定功能,这是一种新发现的靶 mRNA。Flavipin 具有清除 DPPH 自由基的能力,IC50值为7.2 μM,对α-葡萄糖苷酶具有较强的抑制作用,IC50值为 33.8 μM。 | |||
TN5033 |
Skullcapflavone I
|
IL Receptor; Caspase; Prostaglandin Receptor | Apoptosis; GPCR/G Protein; Immunology/Inflammation; Proteases/Proteasome |
Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and PGE(2) release in J774A.1 macrophages and inhibit LPS induced IL-6 production in a concentration dependent manner. Skullcapflavone I se | |||
T35741 |
Gliovirin
|
||
Gliovirin is a fungal metabolite that has been found inT. harzianumand has fungicidal, antimicrobial and anti-inflammatory activities.1It is active against the plant pathogenic fungusP. ultimum(MIC = 60 ng/ml) and the parasiteT. brucei brucei(IC50= 90 ng/ml), but has no effect on the plant pathogenic fungiR. solani,P. omnivorum,T. basicola,R. arrhizus, andV. dahliaeor the bacteriaB. thuringiensis,P. fluorescens, andX. malvacearumwhen used at concentrations up to 1,000 ng/ml.2,3Gliovirin decrease... | |||
TN6667 | Spinacetin | ||
Spinacetin has anti-inflammatory effects, it weakly inhibited nitric oxide production and reduced prostaglandin E2 levels to different extents. It shows the activities in preventing inflammatory processes, which might be at least partially attributed to t | |||
T36329 |
Terpendole I
|
||
Terpendole I is a fungal metabolite that has been found in A. yamanashiensis.1 It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 145 μM) and is active against the bacteria B. cereus and B. subtilis (MICs = 100 μg/ml for both) but not S. aureus, P. aeruginosa, or K. pneumoniae (MICs = >200 μg/ml for all) or the fungus C. albicans (MIC = 200 μg/ml).1,2 It is cytotoxic to HeLa cells with an IC50 value of 52.6 μM.3 |1. Tomoda, H., Tabata, N., Yang, D.-J., et al. Ter... | |||
T36886 |
Pestalotin
|
||
Pestalotin is a fungal metabolite originally isolated from P. cryptomeriaecola with diverse biological activities. It induces reducing sugar release in embryoless rice endosperms when used at concentrations ranging from 3 to 100 mg/L and enhances growth of rice seedlings (O. sativa) when used in combination with gibberellin A3 at concentrations ranging from 30 to 500 mg/L. Pestalotin has antifungal activity, reducing the growth of C. albicans, C. neoformans, T. rubrum, and A. fumigatus (MICs = 1... | |||
T37272 |
9(S),12(S),13(S)-TriHOME
|
||
9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME... | |||
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